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Scipeptide is a professional Manufacturer, Supplier & Exporter of Triptorelin Acetate for the pharmaceutical market,Supply Ability:500g/two weeks,we make sure to check this Triptorelin Acetate chemical on standard quality parameters.

Triptorelin Acetate-Physiochemical properties

      Sequence(Single-Letter Code): Pyr- HWSY(dW)LRPG-NH2

      Sequence(Three-Letter Code): H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

      Number of residues:     9aa

      Molecular weight:     1311.45g/mol

      Extinction coefficient: 6970 M-1cm-1

      Iso-electric point:     pH 8

      Net charge at pH 7:     0.1

      Estimated solubility:     Poor water solubility.

      Storage:store in cool, dry, ventilated place

      PSA:     487.92000

      LogP:     3.20000

      MDL:MFCD00167541

Triptorelin Acetate Description

      Alternate Names:Triptorelin Acetate,PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 PAMOATE SALT;TRIPTORELIN PAMOATE;TRIPTORELIN ACETATE;TRIPTORELIN AMIDE;TRIPTORELIN, [DTRP6]-LH-RH, AMIDE,(D-Trp6)-LHRH; (D-Trp6)-GnRH,6-D-Tryptophan Luteinizing Hormone-Releasing Factor (Swine) Acetate, 6-D-Tryptophan Luteinizing Hormone-Releasing Factor (Pig) Acetate, BIM 21003C, Decapeptyl-Depot, OvuGel

Triptorelin is an analog of gonadotropin-releasing hormone I (GnRH-I); it is a decapeptide that activates the GnRH receptor in the pituitary gland, decreasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Triptorelin inhibits production of cAMP in a Ca2+- and PKC-dependent manner. Triptorelin exhibits anxiolytic and potentially anticancer activities. In vitro, triptorelin

Triptorelin Acetate is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of triptorelin acetate results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Triptorelin Acetate Application

Advanced hormone-dependent prostate cancer
Use in reproduction medicine
Endometriosis
Central precocious puberty

Triptorelin Acetate References

1,S.Fister et al., Cancer Res., 67, 1750 (2007)
2,C.F.Heyns, Am. J. Cancer, 4, 169 (2005)
3,C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004)
4,C.Gründker et al., Gynecol. Oncol., 78, 194 (2000)
5,A.S.Dutta, Drugs Future, 13, 43 (1988)
6,E.Ezan et al., Regul. Peptides, 14, 155 (1986)

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